| Rank | Player | Nationality | Apps | Goals | Club(s) (matches) |
| 1 | Andoni Zubizarreta |  Spain | 622 | 0 | Athletic Bilbao (169)
Barcelona (301)
Valencia (152) |
| 2 | Joaquín Sánchez | Spain | 605 | 76 | Real Betis (390)
Valencia (158)
Málaga (57) |
| 3 | Raúl García | Spain | 567 | 110 | Osasuna (101)
Atlético Madrid (216)
Athletic Bilbao (250) |
| 4 | Raúl | Spain | 550 | 228 | Real Madrid (550) |
| 5 | Eusebio | Spain | 543 | 36 | Valladolid (246)
Atlético Madrid (27)
Barcelona (203)
Celta Vigo (67) |
| 6 | Francisco Buyo | Spain | 542 | 0 | Sevilla (199)
Real Madrid (343) |
| 7 | Manuel Sanchís | Spain | 523 | 33 | Real Madrid (523) |
| 8 | Lionel Messi |  Argentina | 520 | 474 | Barcelona (520) |
| 9 | Iker Casillas | Spain | 510 | 0 | Real Madrid (510) |
| 10 | Sergio Ramos | Spain | 508 | 74 | Sevilla (39)
Real Madrid (469) |
| 11 | Xavi | Spain | 505 | 58 | Barcelona (505) |
| 12 | Miquel Soler | Spain | 504 | 12 | Espanyol (118)
Barcelona (81)
Atlético Madrid (25)
Sevilla (75)
Real Madrid (14)
Zaragoza (39)
Mallorca (152) |
| 13 | Fernando Hierro | Spain | 497 | 106 | Valladolid (58)
Real Madrid (439) |
| 14 | José Mari Bakero | Spain | 483 | 139 | Real Sociedad (223)
Barcelona (260) |
| 15 | Loren | Spain | 482 | 54 | Real Sociedad (354)
Athletic Bilbao (62)
Real Burgos (66) |
| 16 | Joaquín Alonso | Spain | 479 | 65 | Sporting Gijón (479) |
| 17 | José Ramón Esnaola | Spain | 469 | 0 | Real Sociedad (166)
Real Betis (303) |
| 18 | José Ángel Iribar | Spain | 466 | 0 | Athletic Bilbao (466) |
| Donato | Spain | 466 | 49 | Atlético Madrid (163)
Deportivo La Coruña (303) |
| 20 | Miguel Ángel Nadal | Spain | 463 | 34 | Mallorca (255)
Barcelona (208) |
| 21 | Sergio Busquets | Spain | 463 | 11 | Barcelona (463) |
| 22 | Santillana | Spain | 461 | 186 | Real Madrid (461) |
| Alberto Górriz | Spain | 461 | 14 | Real Sociedad (461) |
| 24 | Juan Antonio Larrañaga | Spain | 460 | 15 | Real Sociedad (460) |
| 25 | Manuel Jiménez | Spain | 458 | 8 | Sporting Gijón (420)
Real Burgos (38) |
| 26 | Jesús María Zamora | Spain | 455 | 63 | Real Sociedad (455) |
| 27 | Cristóbal | Spain | 454 | 14 | Barcelona (31)
Oviedo (137)
Logroñés (72)
Espanyol (214) |
| 28 | Aitor Begiristain | Spain | 453 | 90 | Real Sociedad (187)
Barcelona (223)
Deportivo La Coruña (43) |
| 29 | Joseba Etxeberria | Spain | 452 | 90 | Real Sociedad (7)
Athletic Bilbao (445) |
| 30 | Diego | Spain | 450 | 12 | Real Betis (198)
Sevilla (252) |
| 31 | Jesús Navas | Spain | 449 | 25 | Sevilla (449) |
| 32 | Quini | Spain | 448 | 219 | Sporting Gijón (348)
Barcelona (100) |
| 33 | Pedro Munitis | Spain | 447 | 43 | Real Madrid (53)
Deportivo La Coruña (90)
Racing Santander (304) |
| 34 | Ismael Urzaiz | Spain | 445 | 131 | Albacete (11)
Celta Vigo (6)
Rayo Vallecano (20)
Espanyol (41)
Athletic Bilbao (367) |
| 35 | Aritz Aduriz | Spain | 443 | 158 | Athletic Bilbao (316)
Mallorca (69)
Valencia (58) |
| 36 | Andrés Iniesta | Spain | 442 | 35 | Barcelona (442) |
| 37 | Roberto | Spain | 439 | 95 | Valencia (258)
Barcelona (144)
Villarreal (37) |
| Miguel Ángel Fuentes | Spain | 439 | 68 | Real Sociedad (439) |
| 39 | Francisco Gento | Spain | 437 | 128 | Racing Santander (10)
Real Madrid (427) |
| 40 | Francisco | Spain | 436 | 42 | Sevilla (258)
Espanyol (178) |
| Dani Alves |  Brazil | 436 | 26 | Sevilla (175)
Barcelona (261) |
| 42 | Fran | Spain | 435 | 44 | Deportivo La Coruña (435) |
| 43 | Antoine Griezmann |  France | 434 | 170 | Real Sociedad (141)
Atlético Madrid (219)
Barcelona (74) |
| 44 | Gallego | Spain | 433 | 26 | Sevilla (185)
Barcelona (248) |
| Dani Parejo | Spain | 433 | 68 | Real Madrid (5)
Getafe (64)
Valencia (282)
Villarreal (82) |
| 45 | Patxi Salinas | Spain | 432 | 11 | Athletic Bilbao (239)
Celta Vigo (193) |
| 47 | Eloy | Spain | 430 | 77 | Sporting Gijón (227)
Valencia (203) |
| 48 | Gabi | Spain | 429 | 20 | Atlético Madrid (297)
Getafe (32)
Zaragoza (100) |
| 49 | Rafael Gordillo | Spain | 428 | 38 | Real Betis (246)
Real Madrid (182) |
| 50 | Juanfran | Spain | 427 | 16 | Real Madrid (6)
Espanyol (30)
Osasuna (148)
Atlético Madrid (243) |
| 51 | José María Lumbreras | Spain | 423 | 19 | Osasuna (223)
Zaragoza (62)
Real Sociedad (138) |
| 52 | Karim Benzema | France | 422 | 224 | Real Madrid (422)
|
| 53 | Fernando | Spain | 420 | 108 | Valencia (420) |
| Patxi Puñal | Spain | 420 | 22 | Osasuna (420) |
| Santiago Cañizares | Spain | 420 | 0 | Celta Vigo (74)
Real Madrid (41)
Valencia (305) |
| 56 | Gerard Piqué | Spain | 419 | 32 | Zaragoza (22)
Barcelona (397) |
| 57 | Sergio | Spain | 418 | 34 | Espanyol (110)
Deportivo La Coruña (294)
Levante (14) |
| Pablo Alfaro | Spain | 418 | 7 | Zaragoza (107)
Barcelona (7)
Racing Santander (130)
Atlético Madrid (11)
Mérida (34)
Sevilla (129) |
| Roberto López Ufarte | Spain | 418 | 112 | Real Sociedad (363)
Atlético Madrid (27)
Real Betis (28) |
| 60 | Bittor Alkiza | Spain | 417 | 19 | Real Sociedad (130)
Athletic Bilbao (287) |
| Julio Salinas | Spain | 417 | 152 | Athletic Bilbao (68)
Atlético Madrid (75)
Barcelona (146)
Deportivo La Coruña (24)
Sporting Gijón (54)
Alavés (50) |
| Pirri | Spain | 417 | 123 | Real Madrid (417) |
| 63 | Carmelo Cedrún | Spain | 416 | 0 | Athletic Bilbao (334)
Espanyol (82) |
| 64 | José Francisco Molina | Spain | 415 | 0 | Albacete (23)
Atlético Madrid (189)
Deportivo La Coruña (169)
Levante (34) |
| 65 | José Antonio Camacho | Spain | 414 | 9 | Real Madrid (414) |
| Txetxu Rojo | Spain | 414 | 48 | Athletic Bilbao (414) |
| Luis Arconada | Spain | 414 | 0 | Real Sociedad (414) |
| 68 | Fernando Navarro | Spain | 412 | 3 | Barcelona (21)
Albacete (7)
Mallorca (106)
Sevilla (203)
Deportivo La Coruña (75) |
| 69 | Joan Capdevila | Spain | 410 | 36 | Espanyol (60)
Atlético Madrid (31)
Deportivo La Coruña (179)
Villarreal (140) |
| 70 | Alberto Lopo | Spain | 409 | 19 | Espanyol (178)
Deportivo La Coruña (191)
Getafe (40) |
| 71 | Caminero | Spain | 408 | 57 | Valladolid (259)
Atlético Madrid (149) |
| 72 | Raúl Tamudo | Spain | 407 | 146 | Espanyol (340)
Real Sociedad (31)
Rayo Vallecano (36) |
| 73 | Andoni Iraola | Spain | 406 | 33 | Athletic Bilbao (406) |
| 74 | Míchel | Spain | 404 | 97 | Real Madrid (404) |
| 75 | Juan Carlos Valerón | Spain | 403 | 29 | Mallorca (36)
Atlético Madrid (65)
Deportivo La Coruña (289)
Las Palmas (13) |
| 76 | Marcos | Spain | 402 | 25 | Mallorca (171)
Sevilla (209)
Mérida (22) |
| 77 | César | Spain | 401 | 0 | Real Valladolid (206)
Real Madrid (20)
Zaragoza (110)
Valencia (63)
Villarreal (2) |
| Adelardo | Spain | 401 | 73 | Atlético Madrid (401) |
| 79 | Luis Enrique | Spain | 400 | 103 | Sporting de Gijón (36)
Real Madrid (157)
Barcelona (207) |
